Copper-Catalyzed Sulfonylation of Cyclobutanone Oxime Esters with Sulfonyl Hydrazides

Abstract A copper-catalyzed radical cross-coupling of cyclobutanone oxime esters with sulfonyl hydrazides has been developed. The copper-based catalytic system proved crucial for cleavage the C−C bond oximes and selective C–S bond-formation involving persistent sulfonyl-metal intermediates. This protocol is distinguished by low-cost system, which does not require ligand, base, or toxic cyanide salt, use readily accessible starting materials, as well broad substrate scope, providing an efficient approach to various diversely substituted cyano-containing sulfones.